Mitochondria as sensors and regulators of calcium signalling
作者： Rosario Rizzuto , Diego De Stefani , Anna Raffaello , Cristina Mammucari
DOI: 10.1038/NRM3412
关键词: Voltage-dependent calcium channel 、 Cytosol 、 Calcium 、 Mitochondrial calcium uptake 、 Biology 、 LETM1 、 Biochemistry 、 Mitochondrion 、 Cell biology 、 Calcium signaling 、 Autophagy
摘要: During the past two decades calcium (Ca2+) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca2+ levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca2+ transporters has been revealed, opening new perspectives for investigation and molecular intervention.
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