Enhancement by other compounds of the anti-cancer activity of vitamin D3 and its analogs

摘要: Abstract Differentiation therapy holds promise as an alternative to cytotoxic drug of cancer. Among compounds under scrutiny for this purpose is the physiologically active form vitamin D3, 1,25-dihydroxyvitamin and its chemically modified derivatives. However, propensity D3 analogs increase levels serum calcium has so far precluded their use in cancer patients except limited clinical trials. This article summarizes range that have been shown differentiation-inducing antiproliferative activities analogs, discusses possible mechanistic basis synergy several selected combinations. The agents discussed include those activity own increased by combination with or such retinoids transforming growth factor-β plant-derived antioxidants, curcumin carnosic acid. other here are dexamethasone, nonsteroidal anti-inflammatory drugs, inhibitors cytochrome P450 enzymes, example, ketoconazole. Thus, recent data illustrate there extensive, but largely unexplored, opportunities develop combinatorial, differentiation-based approaches chemoprevention chemotherapy human