Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.
作者： David Harding , Paul B. Baines , David Brull , Vassilis Vassiliou , Ian Ellis
DOI: 10.1164/AJRCCM.165.8.2108089
关键词: Gastroenterology 、 Internal medicine 、 Captopril 、 Angiotensin II 、 Genotype 、 El Niño 、 Angiotensin-converting enzyme 、 Respiratory disease 、 Meningococcal disease 、 Immunology 、 Risk of mortality 、 Medicine
摘要: Critical illness outcome may be causally related to inflammatory response severity. Given that tissue angiotensin-converting-enzyme (ACE) regulates such responses and the deletion (D) [rather than insertion (I)] variant of ACE gene is associated with higher levels, DD genotype might a poorer in uniform infectious disease state. Illness severity (Pediatric RIsk Mortality score, Glasgow Meningococcal Septicaemia Prognostic Score [GMSPS], clinical course) was recorded for consecutive white patients meningococcal (n = 110, 34 genotype, 61 male, aged 49.4 ± 5.4 months) referred Royal Liverpool Children's Hospital, UK. Compared children ⩾ I allele, 14% predicted risk mortality (p 0.038), GMSPS (DD 9.4 0.5, ID/II 7.7 0.4 [mean SEM], p 0.013), greater prevalence inotropic support (76% versus 55%, 0.03) ventilation (82% 63%, 0.04), longer ...
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