Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population

摘要: Serum levels of uric acid (UA) are associated with metabolic syndrome (MetS). However, no study has been aimed to investigate whether baseline UA is a predictor MetS in Japanese population. The multivariable adjusted hazard ratios (HRs) through 3 years were calculated for each 1 SD increase UA, the higher quartiles compared lowest quartile, and hyperuricemia defined as ≥7.0 mg/dl men ≥6.0 women apparently healthy 1,606 aged 51.7 ± 9.4 953 51.6 who visited medical check-up center Japan. HRs (95 % confidence interval; p value) 1.282 (1.097-1.499; 0.002) 1.354 (1.041-1.762; 0.024) 2.206 (1.344-3.620; 3.110 (1.121-8.627; 0.029) highest quartile 1.900 (1.376-2.622; <0.001) 2.088 (1.040-4.190; 0.038) adjusting pre-existing components MetS, age, smoking, drinking, physical activity, use antihypertensive, antihyperlipidemic, antidiabetic medications histories coronary heart disease stroke. significant association was found between longitudinal changes incident MetS. Baseline an independent health screening