Chapter nine Engineering pathway enzymes to understand the function and evolution of sterol structure and activity

摘要: This chapter discusses first the structures of sterols to establish limits diversity, followed by a brief review sterol biosynthesis and structure-activity studies provide background information on factors that can impact phylogenesis. The also outlines parallel strategies performed with critical enzyme phytosterol synthesis, methyltransferase (SMT) show mutations engineered in structure lead change structure, thereby affecting cell growth, maturation evolution. function, enzymology, evolution phytosterols are an area which has received little attention. In spite numerous indications C-methylation reaction plants, fungi, protozoa essential disturb homeostasis these organisms be therapeutic value, bulk evidence along lines comes from scattered observations.