A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection

摘要: The study was undertaken to compare the safety and efficacy of twice-daily ciprofloxacin for 3 days with standard 7 day therapy either co-trimoxazole or nitrofurantoin in treatment women acute, uncomplicated urinary tract infections (UTI). This multicentre, prospective, randomized, double-blind trial compared oral (100 mg bd) (160/800 days. Bacteriological clinical evaluations were performed at entry, during 4-10 4-6 weeks after completion therapy. primary parameter eradication causative organism following treatment. Of 713 enrolled evaluable safety, 521 (168 ciprofloxacin, 174 co-trimoxazole, 179 nitrofurantoin). Escherichia coli (83%) most frequently isolated pathogen all groups. reported 88% patients, 93% patients 86% patients. At week follow-up, had statistically significantly higher rates (91%) than (79%; 95% confidence limit (CL) = -20.6%, -3.9%) (82%; CL -17.1%, -0.9%). Clinical resolution follow-up similar among three overall incidence treatment-emergent adverse events not different (P 0.093) drug regimens, although associated a greater number < 0.05). Ciprofloxacin also caused fewer episodes nausea other agents 0.01).