Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of H2S-Producing Enzymes in Multiple Sclerosis

摘要: The aim of this study was to examine the in vitro effects slow-releasing H2S donor GYY4137 on immune cells involved pathogenesis central nervous system (CNS) autoimmune disease, multiple sclerosis (MS). specifically potentiated TGF-β expression and production dendritic significantly reduced IFN-γ IL-17 lymph node spinal cord T obtained from mice immunized with CNS antigens. Both proportion FoxP3+ regulatory CD4+ cells, percentage IL-17+ were upon culturing GYY4137. Interestingly, peripheral blood mononuclear MS patients had a lower H2S-producing enzyme, 3-mercaptopyruvate-sulfurtransferase (MPST), comparison those healthy donors. A significant inverse correlation between MPST several pro-inflammatory factors also observed. Further studies relevance observed results for therapy are warranted.