Intrinsic brain indices of verbal working memory capacity in children and adolescents.

摘要: Working memory (WM) is central to the acquisition of knowledge and skills throughout childhood adolescence. While numerous behavioral task-based functional magnetic resonance imaging (fMRI) studies have examined WM development, few used resting-state fMRI (R-fMRI). Here, we present a systematic R-fMRI examination age-related differences in neural indices verbal performance cross-sectional pediatric sample (ages: 7-17; n=68), using data-driven approaches. Verbal capacity was measured with digit span task, commonly educational clinical assessment. We found distinct forward (DSF) backward (DSB) performance, reflecting their unique neuropsychological demands. Regardless age, DSB related intrinsic properties brain areas previously implicated attention cognitive control, while DSF less storage (precuneus, lateral visual areas). From developmental perspective, exhibited more robust brain-behavior relationships than DSB, broader range networks (ventral attention, default, somatomotor, limbic networks)--including number regions not associated (angular gyrus, subcallosum). These results highlight importance examining neurodevelopment considering beyond "usual suspects".