Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis

摘要: Abstract p73 and p63 are recently cloned genes that share considerable structural functional homologies with the p53 tumor suppressor gene. These genes, unlike p53, express multiple mRNA isoforms variable biologic functions, their nature has yet to be confirmed. To determine interrelationship between these in tumorigenesis of head neck squamous carcinoma (HNSC), we performed immunohistochemical analyses protein products compared data clinicopathologic parameters 38 patients. In histologically normal epithelium, showed similar basal and/or parabasal expression, but was weaker discontinuous. staining noted more suprabasal cellular layers stronger. dysplasias, all three markers manifested gradual increase extent intensity expression histologic progression. carcinomas, most frequently expressed (94.7%), followed by (68.4%) (52.6%). Significant statistical correlation only expressions (P =.04). Although no found or p73, p53-negative tumors overexpressed either p73. associated distant metastasis perineural/vascular invasion. Our study indicates (1) may represent an early event HNSC tumorigenesis, (2) lack suggests independent compensatory role, (3) play a part progression, (4) function as oncogenes development tumors. H UM P ATHOL 33:158-164. Copyright 2002, Elsevier Science (USA). All rights reserved.