Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic Pathway
作者： Mariana S. Cardoso , Caroline Junqueira , Ricardo C. Trigueiro , Hosam Shams-Eldin , Cristiana S. Macedo
DOI: 10.1371/JOURNAL.PNTD.0002369
关键词: Biochemistry 、 Trypanosoma cruzi 、 Immune system 、 Cell biology 、 Innate immune system 、 Gene expression profiling 、 Gene 、 Biology 、 Virulence 、 Biosynthesis 、 Chagas disease 、 Public Health, Environmental and Occupational Health 、 Infectious Diseases
摘要: Background Trypanosoma cruzi is a protist parasite that causes Chagas disease. Several proteins are essential for virulence and involved in host immune responses anchored to the membrane through glycosylphosphatidylinositol (GPI) molecules. In addition, T. GPI anchors have immunostimulatory activities, including ability stimulate synthesis of cytokines by innate cells. Therefore, genes related anchor biosynthesis constitute potential new targets development better therapies against
fiocruz.br参考文章(82)
Maria Júlia M. Alves, Walter Colli, Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures. Sub-cellular biochemistry. ,vol. 47, pp. 58- 69 ,(2008) , 10.1007/978-0-387-78267-6_4
R. Daniel Gietz, Robin A. Woods, Yeast Transformation by the LiAc/SS Carrier DNA/PEG Method Yeast Protocols. ,vol. 313, pp. 107- 120 ,(2014) , 10.1385/1-59259-958-3:107
Rosa M. de Lederkremer, Rosalía Agusti, Glycobiology of Trypanosoma cruzi. Advances in Carbohydrate Chemistry and Biochemistry. ,vol. 62, pp. 311- 366 ,(2009) , 10.1016/S0065-2318(09)00007-9
Ramin Mazhari-Tabrizi, Michaela Blank, Dominik Mumberg, Martin Funk, Ralph T. Schwarz, Volker Eckert, Chromosomal promoter replacement in Saccharomyces cerevisiae: construction of conditional lethal strains for the cloning of glycosyltransferases from various organisms. Glycoconjugate Journal. ,vol. 16, pp. 673- 679 ,(1999) , 10.1023/A:1007132907235
M.L. Güther, M.L. de Almeida, N Yoshida, M.A. Ferguson, Structural studies on the glycosylphosphatidylinositol membrane anchor of Trypanosoma cruzi 1G7-antigen. The structure of the glycan core. Journal of Biological Chemistry. ,vol. 267, pp. 6820- 6828 ,(1992) , 10.1016/S0021-9258(19)50500-2
J PREVIATO, R WAIT, C JONES, G DOSREIS, A TODESCHINI, N HEISE, L MENDONCAPREVIATO, Glycoinositolphospholipid from Trypanosoma cruzi: Structure, Biosynthesis and Immunobiology Advances in Parasitology. ,vol. 56, pp. 1- 41 ,(2003) , 10.1016/S0065-308X(03)56001-8
ROSA M. DE LEDERKREMER, ROSALÍA AGUSTI, ROBERTO DOCAMPO, Inositolphosphoceramide Metabolism in Trypanosoma cruzi as Compared with other Trypanosomatids Journal of Eukaryotic Microbiology. ,vol. 58, pp. 79- 87 ,(2011) , 10.1111/J.1550-7408.2011.00533.X
M. Benghezal, A. Benachour, S. Rusconi, M. Aebi, A. Conzelmann, Yeast Gpi8p is essential for GPI anchor attachment onto proteins. The EMBO Journal. ,vol. 15, pp. 6575- 6583 ,(1996) , 10.1002/J.1460-2075.1996.TB01048.X
P Orlean, Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiae. Molecular and Cellular Biology. ,vol. 10, pp. 5796- 5805 ,(1990) , 10.1128/MCB.10.11.5796
V.L. Pereira-Chioccola, S. Schenkman, M.M. Rodrigues, M.A. Ferguson, L.R. Travassos, A. Acosta-Serrano, T. Souto-Padron, I. Correia de Almeida, Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies Journal of Cell Science. ,vol. 113, pp. 1299- 1307 ,(2000) , 10.1242/JCS.113.7.1299