Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia.

摘要: Physical activities can have intrinsic motivational or reinforcing properties. The choice to engage in voluntary physical activity is undertaken relation the selection of other alternatives, such as sedentary behaviors, drugs, food intake. mesolimbic dopamine (DA) system plays a critical role behavioral activation exertion effort, and DA antagonism depletion induces anergia effort-based decision-making tasks. However, little known about neural mechanisms underlying processes that establish preferences for vs. activity-based reinforcers. In present work with male CD1 mice, we evaluated effect tetrabenazine (TBZ), DA-depleting agent, on three-choice T-maze task developed assess preference between reinforcers different requirements sensory properties [i.e., running wheel (RW) sweet pellets neutral nonsocial odor]. We also studied effects TBZ forced swim test (FST), which measures climbing swimming stressful setting, anxiety tests [dark-light (DL) box elevated plus maze (EPM)]. task, reduced time but increased spent consuming sucrose, thus indicating relatively intact sucrose reinforcement. was not mimicked by manipulations change value reinforcers, making RW aversive harder move, food-restricting animals, inducing binge-like eating pattern, introducing social odors. FST, decreased (most active behavior) immobility did affect DL EPM. These results indicate could be useful assessing modulation exercise based effort requirements, differentiating those from changes produced altering restriction state, stress during testing.