The role of flexible polymer interconnects in chronic tissue response induced by intracortical microelectrodes--a modeling and an in vivo study.
作者： Jeyakumar Subbaroyan , Daryl R. Kipke
DOI: 10.1109/IEMBS.2006.260517
关键词: Materials science 、 Polydimethylsiloxane 、 In vivo 、 Implant failure 、 Glial fibrillary acidic protein 、 Polyimide 、 Biomedical engineering 、 Implant 、 Strain (chemistry) 、 Microelectrode
摘要: Chronic tissue response induced by tethering is one of the major causes for implant failure in intracortical microelectrodes. In this study, we had explored hypothesis that flexible interconnects could provide strain relief against forces "micromotion" and hence result maintaining a healthy surrounding implant. Finite element modeling results indicated interconnects, namely polyimide (E=2 GPa) polydimethylsiloxane (PDMS, E=6 MPa), reduced interfacial 66% two orders magnitude, respectively. Quantitative immunohistochemistry significant neuronal loss occurred up to 60 mum from interface. This was strongly correlated both glial fibrillary acidic protein (GFAP) expression simulated as function distance away
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