Survey of Anti-angiogenesis Strategies

摘要: The field of angiogenesis modulation is at a major crossroad. Tremendous advances in basic science this are providing excellent support to the concept that contrast lack strong clinical point. With regard big gap between experimental data and data, best model human malignancy malignancy, models diabetic retinopathy (DR) age-related macular degeneration (AMD) DR AMD patients. Clinical outcome should include benefit/risk ratio, hard end points (mortality quality life as opposed increased microvascular density with pro-angiogenesis agents or tumor size reduction anti-angiogenesis agents), cost effectiveness.