Wavelength Dependence of Skin Cancer Induction by Ultraviolet Irradiation of Albino Hairless Mice

摘要: Information on the variation in carcinogenicity with wavelength is crucial risk assessments for skin cancers induced by UV radiation. Until recently (lambda) dependencies of other detrimental effects, such as sunburn, have been used substitutes. Direct information lambda dependency can only be obtained from animal experiments. To this end we accumulated a large data set tumors chronic exposure albino SKH:HR1 mice (14 different broadband sources and about 1100 mice); come Photobiology Unit former Skin Cancer Hospital Philadelphia Department Dermatology University Utrecht. The was extracted (a statistically satisfactory description chi 2 = 13.4, df 7) represented Utrecht-Philadelphia action spectrum, i.e., factors to weight exposures at wavelengths according their respective effectiveness (inversely proportional daily required median tumor induction time 300 days). fits already available spectra proved poor (chi > 60, 11). maximum found 293 nm, above 340 nm showed shoulder 10(-4) maximum. A sensitivity analysis final solution margin uncertainty an gap below 280 nm. responses present transformed coherent, common dose-response relationship proper spectral weighting single spectrum.