Balance of human choline kinase isoforms is critical for cell cycle regulation: Implications for the development of choline kinase-targeted cancer therapy.
作者： Jens Gruber , Wei Cun See Too , Mun Teng Wong , Arnon Lavie , Theresa McSorley
DOI: 10.1111/J.1742-4658.2012.08573.X
关键词: Molecular biology 、 Biology 、 Cell cycle 、 Cell biology 、 Signal transduction 、 Phosphorylcholine 、 Cancer cell 、 Choline kinase 、 RNA interference 、 Gene silencing 、 Gene knockdown
摘要: … of cells re-entered cell cycle and died by apoptosis in the absence of CKα. Simultaneous silencing of CKα and CKβ in G0/G1-arrested cells did not induce apoptotic cell … that inhibition of …
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