Chapter 8. Antithrombotic Agents

摘要: Publisher Summary This chapter describes the development and clinical studies of antithrombotic agents. The therapeutic approaches to treatment thrombosis include inhibition platelet aggregation, blood coagulation, enhancement fibrinolytic process. agents involved affect function or act on coagulation mechanisms either by inhibiting formation enhancing breakdown fibrin. In this regard, it is important differentiate between a clot thrombus. effects natural prostaglandins (PG) have been studied extensively. As group, they are generally inhibitors ADP-induced aggregation. PGE 1 far most potent at least two orders magnitude. 2 differs in that exhibits biphasic activity; concentrations less than those required for inhibition, potentiates Evidence continues support hypothesis aggregation release reaction inhibited raised levels intracellular cyclic AMP. inhibitory such diverse as , dipyridamole, methylxanthines papaverine all appear be mediated nucleotide.