Neonatal outcome after preimplantation genetic diagnosis.

摘要: Objective To examine whether embryo biopsy for preimplantation genetic diagnosis (PGD) influences neonatal outcomes. Design Prospective follow-up cohort. Setting Tertiary university-affiliated medical center. Patient(s) 242 children born after PGD, intracytoplasmic sperm injection (ICSI) (158 singletons and 42 twins pairs in each group), 733 a spontaneous conception (SC) (493 singletons, 120 pairs), matched maternal age, parity, body mass index. Intervention(s) None. Main Outcome Measure(s) Gestational birth weight, prematurity ( Result(s) For the mean weight was higher SC compared with ICSI but not PGD. Mean gestational ages were lower PGD SC. The low intrauterine growth restriction rates 4.4%, 12.0%, 5.7% 5.1%, 9.5%, 5.5% ICSI, SC, respectively. Similar results found when controlled number of embryos transferred cryopreservation. exhibited similar less statistically significant trends. Polar blastomere biopsies provided Conclusion(s) Embryo itself did cause or despite worsened outcomes pregnancies may be due to infertility itself.