Effect of Selected Plant Phenolics on Fe2+-EDTA-H2O2 System Mediated Deoxyribose Oxidation: Molecular Structure-Derived Relationships of Anti- and Pro-Oxidant Actions

摘要: In the presence of transition metal ions and peroxides, polyphenols, well-known dietary antioxidants, can act as pro-oxidants. We investigated effect 13 polyphenols their metabolites on oxidative degradation deoxyribose by an •OH generating Fenton system (Fe2+-ethylenediaminetetraacetic acid (EDTA)-H2O2). The relationship between phenolics pro-oxidant/anti-oxidant effects molecular structure was analyzed using multivariate analysis with multiple linear regression a backward stepwise technique. Four revealed significant inhibitory OH-induced degradation, ranging from 54.4% ± 28.6% (3,4-dihydroxycinnamic acid) to 38.5% 10.4% (catechin) (n = 6), correlating number –OH substitutions (r 0.58). Seven augmented highest enhancement at 95.0% 21.3% (quercetin) 60.6% 12.2% (phloridzin). pro-oxidant correlated (p < 0.05) groups 0.59), aliphatic substitutes −0.22) weakly occurrence catechol within compound molecule 0.17). Selective supplementation exhibiting activity may increase possibility systemic stress in patients treated medications containing chelating properties or those high plasma concentrations H2O2 non-transferrin bound iron.