Review of salt consumption and stomach cancer risk: epidemiological and biological evidence.

摘要: Stomach cancer is still the fourth most common cancer; thus, it remains an important public health burden worldwide, especially in developing countries. The remarkable geographic variations rates of stomach indicate that dietary factors, including a range food groups to which salt and/or nitrates have been added, may affect risk. In this paper, we review results from ecologic, case-control and cohort studies on relationship between or salted foods majority ecological indicated average intake each population was closely correlated with gastric mortality. Most showed similar results, indicating moderate high increase risk for highest level consumption. overall are not totally consistent, but suggestive direct association. Since has Helicobacter pylori (H pylori) infection, possible these two factors synergize promote development cancer. Additionally, also cause through directly damaging mucus, improving temporary epithelial proliferation incidence endogenous mutations, inducing hypergastrinemia leads eventual parietal cell loss progression Based considerable evidence ecological, worldwide mechanistic plausibility, limitation consumption practical strategy preventing