Immunohistochemical Evaluation for Hormone Receptors in Breast Cancer: A Practically Useful Evaluation System and Handling Protocol

作者: Shinobu Umemura , Masafumi Kurosumi , Takuya Moriya , Tetsunari Oyama , Kohji Arihiro

DOI: 10.2325/JBCS.13.232

关键词: Breast cancerProtocol (science)MedicineGynecologyMedical physicsRoutine practiceHormone receptorEvaluation systemStandardizationScoring systemTask force

摘要: This article reviews the current status of hormone receptor evaluation in and out Japan, introduces proposed working protocol task force for Adequate immunohistochemical routine practice breast cancer by Japanese Breast Cancer Society. Understanding principles developmental process immunohistochemisty helps us to utilize a scoring system adequately. Methodologies examination procedures are briefly introduced. Each is based on different principles. The takes into account reproducibility results among observers, institutions staining procedures, which justified situation Japan. Future directions standardization also described.

参考文章(15)
Jennet M. Harvey, Gary M. Clark, C. Kent Osborne, D. Craig Allred, Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer Journal of Clinical Oncology. ,vol. 17, pp. 1474- 1474 ,(1999) , 10.1200/JCO.1999.17.5.1474
McCarty Ks, Cox Eb, Miller Ls, Konrath J, Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Archives of Pathology & Laboratory Medicine. ,vol. 109, pp. 716- 721 ,(1985)
S Detre, G Saclani Jotti, M Dowsett, A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas. Journal of Clinical Pathology. ,vol. 48, pp. 876- 878 ,(1995) , 10.1136/JCP.48.9.876
G. L. Greene, C. Nolan, J. P. Engler, E. V. Jensen, Monoclonal antibodies to human estrogen receptor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 5115- 5119 ,(1980) , 10.1073/PNAS.77.9.5115
STANLEY G. KORENMAN, BETTY A. DUKES, Specific Estrogen Binding by the Cytoplasm of Human Breast Carcinoma The Journal of Clinical Endocrinology and Metabolism. ,vol. 30, pp. 639- 645 ,(1970) , 10.1210/JCEM-30-5-639
Robin Leake, Diana Barnes, Sarah Pinder, Ian Ellis, Liz Anderson, Tom Anderson, Ruth Adamson, Tony Rhodes, Keith Miller, Rosemary Walker, Immunohistochemical detection of steroid receptors in breast cancer: a working protocol Journal of Clinical Pathology. ,vol. 53, pp. 634- 635 ,(2000) , 10.1136/JCP.53.8.634
Geoffrey L. Greene, Elwood V. Jensen, Monoclonal antibodies as probes for estrogen receptor detection and characterization Journal of Steroid Biochemistry. ,vol. 16, pp. 353- 359 ,(1982) , 10.1016/0022-4731(82)90045-0
David Hockenbery, Gabriel Nuñez, Curt Milliman, Robert D. Schreiber, Stanley J. Korsmeyer, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death Nature. ,vol. 348, pp. 334- 336 ,(1990) , 10.1038/348334A0