Molecular mechanism of adaptive response to alkylating agents.
作者： Mutsuo Sekiguchi , Hidemasa Kondo , Kunihiko Sakumi , Yusaku Nakabeppu
DOI: 10.1007/978-1-4684-5182-5_19
关键词: SOS response 、 Repressor lexA 、 DNA damage 、 Cell biology 、 Adaptive response 、 DNA repair 、 Carcinogen 、 Molecular biology 、 Molecular mechanism 、 Escherichia coli 、 Biology
摘要: Alkylating agents are potent mutagens and carcinogens, organisms respond in a complex manner to these agents. Growth of Escherichia coli the presence low levels simple alkylating agents, such as N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), results marked increase resistance cells both mutagenic lethal effects challenging doses same (24). This adaptive response is distinct from previously characterized pathways DNA repair, particularly SOS response, another inducible effect resulting damage. The adaptation does not lead expression functions, recA lexA mutant that unable perform repair can be adapted MNNG (8, 27).
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