Emergent Properties of Networks of Biological Signaling Pathways

作者: Upinder S Bhalla , Ravi Iyengar , None

DOI: 10.1126/SCIENCE.283.5400.381

关键词: Signal modulationProcess (engineering)BistabilityMultiple timeNeuroscienceBiochemical reactionsBiological signalingSignalComputer scienceSignal transduction

摘要: … be useful in understanding the properties of these networks. … reactions, we used the basic chemical reaction schemes of … of PP1 and CaN do, however, lead to a prolongation of CaMKII …

参考文章(43)
R.A. Nemenoff, S. Winitz, N.X. Qian, V. Van Putten, G.L. Johnson, L.E. Heasley, Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. Journal of Biological Chemistry. ,vol. 268, pp. 1960- 1964 ,(1993) , 10.1016/S0021-9258(18)53948-X
T.W. Rall, Earl W. Sutherland, Walter D. Wosilait, The relationship of epinephrine and glucagon to liver phosphorylase. III. Reactivation of liver phosphorylase in slices and in extracts. Journal of Biological Chemistry. ,vol. 218, pp. 483- 495 ,(1956) , 10.1016/S0021-9258(18)65911-3
C M Schworer, R J Colbran, J R Keefer, T R Soderling, Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains Journal of Biological Chemistry. ,vol. 263, pp. 13486- 13489 ,(1988) , 10.1016/S0021-9258(18)68264-X
U Staubli, D Chun, Factors regulating the reversibility of long-term potentiation The Journal of Neuroscience. ,vol. 16, pp. 853- 860 ,(1996) , 10.1523/JNEUROSCI.16-02-00853.1996
M.P. Carroll, W.S. May, Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. Journal of Biological Chemistry. ,vol. 269, pp. 1249- 1256 ,(1994) , 10.1016/S0021-9258(17)42250-2
O. Jacobowitz, J. Chen, R.T. Premont, R. Iyengar, Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment. Journal of Biological Chemistry. ,vol. 268, pp. 3829- 3832 ,(1993) , 10.1016/S0021-9258(18)53547-X
R. D. Traub, R. K. Wong, R. Miles, H. Michelson, A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. Journal of Neurophysiology. ,vol. 66, pp. 635- 650 ,(1991) , 10.1152/JN.1991.66.2.635
Walter Kolch, Gisela Heidecker, Georg Kochs, Richard Hummel, Haleh Vahidi, Harald Mischak, Günter Finkenzeller, Dieter Marmé, Ulf R. Rapp, Protein kinase Cα activates RAF-1 by direct phosphorylation Nature. ,vol. 364, pp. 249- 252 ,(1993) , 10.1038/364249A0
John Lisman, The CaM kinase II hypothesis for the storage of synaptic memory Trends in Neurosciences. ,vol. 17, pp. 406- 412 ,(1994) , 10.1016/0166-2236(94)90014-0
Robert D. Blitzer, Tony Wong, Rabin Nouranifar, Ravi Iyengar, Emmanuel M. Landau, Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region Neuron. ,vol. 15, pp. 1403- 1414 ,(1995) , 10.1016/0896-6273(95)90018-7