The radioisotope stent for the prevention of restenosis.

摘要: The use of intracoronary stenting has revolutionized catheter-based revascularization obstructive coronary artery disease. These devices provide excellent scaffolding, predictable immediate success with the creation a large, dissection-free luminal cross-section and improved longterm outcomes, when compared to “plain old balloon angioplasty”. Despite these improvements restenosis still occurs at unacceptable rate, particularly in smaller vessels longer lesions. In this article we review concept using stent implanted low activities radioisotope as means inhibit proliferative process that is believed initiate in-stent restenosis. potential advantages, well limitations intravascular brachytherapy are reviewed. This approach been shown be effective certain animal models initial clinical results Phase I safety trials will summarized. Future directions for technology, including evaluation new designs radioiotopes discussed. early more than 170 implants activity32P Palmaz-Schatz BX radioactive stents have demonstrated procedural 30-day event-free survival. Further dose finding anticipated 1998. Implementation large scale randomized trial commence if efficacy data suggest therapeutic effect from technology. Thus, future studies focus on optimal design evaluate alternative isotopes dosing strategies.