Signal Transduction Pathways Involved in Glucocorticoid Actions

摘要: Glucocorticoids are the only effective antiinflammatory therapy for asthma. Recently new insights have been gained into molecular mechanisms of their effects. Asthma is characterized by increased expression multiple inflammatory genes that regulated proinflammatory transcription factors, such as nuclear factor-κB, which activate coactivator molecules switch on gene through acetylation core histones. suppress activated in asthmatic airways mainly reversing histone binding glucocorticoid receptors (GR) to coactivators and recruitment deacetylase-2 (HDAC2) complex. Activated GR also bind promoters certain transcription, resulting proteins, MKP-1, inhibits MAP kinase signaling pathways. Glucocorticoid may interact with other recognition sites inhibit example several linked side