Human Genetic Variation Influences Enteric Fever Progression.

摘要: In the 21st century, enteric fever is still causing a significant number of mortalities, especially in high-risk regions world. Genetic studies involving genome and transcriptome have revealed broad set candidate genetic polymorphisms associated with susceptibility to severity fever. This review attempted explain discuss past most recent findings on human variants affecting progression Salmonella typhoidal species infection, particularly toll-like receptor (TLR) 4, TLR5, interleukin (IL-) natural resistance-associated macrophage protein 1 (NRAMP1), VAC14, PARK2/PACRG, cystic fibrosis transmembrane conductance regulator (CFTR), major-histocompatibility-complex (MHC) class II III. These disease or patients could be related multiple mechanisms eliminating both intracellular extracellular species. Here, we also highlighted limitations reported, which led inconclusive results association studies. Nevertheless, knowledge obtained through this may shed some light development risk prediction tools, novel therapies as well strategies towards developing personalised typhoid vaccine.