The Ideal Drug Delivery System: A Look into the Future

作者: JEAN-MARC AIACHE

DOI: 10.1089/JAM.1991.4.323

关键词: Dispersion (chemistry)PropaneAerosol PropellantsProcess engineeringPlastic bagNanotechnologyButaneDrug deliveryPropellantMaterials scienceCompressed air

摘要: ABSTRACT In the very near future, CFC manufacturers are going to be obliged stop their production as a result of "Montreal protocole on substances that deplete ozone layer". The replacement these propellants by other fluorinated ones will possible soon lack toxicity has been demonstrated. Other substitution like haliphatic hydrocarbons (butane, propane) or compressed air generated device system itself user himself also under development. pulverisation can obtained pressure classical propellant onto an aluminium plastic bag. dispersion is achieved means regulator which positioned into valve. hand-operated spray pumps with without compression allow obtention ofvery small particles though delivered doses reduced. However, few new devices have metered valves, they not yet suitable for pulmonary administration.

参考文章(1)
SP Newman, Metered dose pressurized aerosols and the ozone layer European Respiratory Journal. ,vol. 3, pp. 495- 497 ,(1990)