THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

摘要: A group of apparently unrelated endocrine cells, some in glands, others nonendocrine tissues, share a number cytochemical and ultrastructural characteristics. These characteristics, from the initial letters four which term APUD is derived, indicate possession common metabolic pattern synthetic, storage secretion mechanisms. It postulated that various characteristics reflect production hormone precursor protein has predominantly random coil conformation. Several explanations are possible to account for but if fact, ancestor only candidate neural crest cell.