Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study

摘要: Obesity is significant problem involving eating behavior and peripheral metabolic conditions. The effect of carbohydrate fat restriction on appetite regulation, fibroblast growth factor 21 (FGF21) leptin in children has not been defined. Our objective was to compare the both diets. One hundred twenty with body mass index (BMI) higher than equivalent 30 kg/m2 for an adult, as corrected gender age were randomly assigned (n = 60) a low-carbohydrate (L-CHO) diet or low-fat (L-F) 2 months. Fifty-three (88.3 %) subjects low-carbohydrate-diet 45 (75 %) completed study. Anthropometric measures, FGF21 levels measured before after intervention. Comparison data groups carried out using t-test independent variables. Intragroup comparisons each dietary treatments performed ANOVA repeated measures. Factors associated FGF21, satiety, analyzed by multiple regression. After diets, weight, leptin, food responsiveness, enjoyment significantly decreased high density lipoprotein cholesterol (HDL) increased, but decreased. Before interventions triglycerides. diet, satiety lower screen time (p < 0.04) insulin (p < 0.05). Both restrictions improved hormonal parameters obese children. indicator beneficial response younger 2 months adaptation observed.