Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells
作者： Jolien Suurmond , Jeroen N. Stoop , Felice Rivellese , Aleida M. Bakker , Tom W. J. Huizinga
关键词: Toll-like receptor 、 T helper cell 、 Cytokine 、 Basophil 、 Degranulation 、 Receptor 、 Immunology 、 Biology 、 Immunoglobulin E 、 Acquired immune system
摘要: Basophils are mostly known for their involvement in allergic reactions. Recent studies mice indicate a role basophils the induction of adaptive immunity, especially T helper 2 (Th2) responses. Therefore, it would be highly important to understand how respond pathogen-associated molecules, such as ligands toll-like receptors (TLRs), and if could promote Th2 responses via these stimuli. To this end, activation TLRs combination with IgE was studied, well its effect on cell skewing. Using quantitative PCR, we demonstrated presence mRNA 1-8 human basophils. responded TLR triggering differential cytokine production, but not degranulation. Simultaneous led synergy production IL-4, IL-8, IL-13, RANTES. Furthermore, synergistic effects mediated by TLR-4 allowed robust skewing upon naive CD4⁺ cells. Our data show that IgE-mediated cytokines produced can differentiation. These results regulation T-cell humans.
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