Sialomucin complex in tumors and tissues
作者： Kermit L Carraway
DOI: 10.2741/A204
关键词: Mucus 、 Receptor tyrosine kinase 、 Cell 、 Glycoprotein 、 Transmembrane domain 、 Mucin 、 Transmembrane protein 、 Cell biology 、 Chemistry 、 Immune system 、 General Biochemistry, Genetics and Molecular Biology 、 General Immunology and Microbiology 、 General Medicine
摘要: Sialomucin complex (SMC) is a high Mr glycoprotein heterodimer, originally discovered on the cell surfaces of ascites sublines highly metastatic 13762 rat mammary adenocarcinoma, and composed mucin (ASGP-1) transmembrane (ASGP-2) subunits. SMC encoded by single gene synthesized as large precursor protein which cleaved into its subunits early in transit to surface. exhibits behavior typical both membrane secreted mucins. In cells, it found only form, creating protective barrier at surface reduce adhesiveness protect tumor from immune killing. Normal tissues express formand non-membrane may be either constitutive or regulated, secretory granule mechanisms. This soluble form proposed contribute multilayer mucus gels epithelia, though also play other roles. ASGP-2 contains two EGF-like domains, one binds receptor tyrosine kinase ErbB-2. Thus, bifunctional protein, serving function domain possibly playing role proliferation cells repair processes necessary for maintenance damaged epithelia.
bioscience.org参考文章(72)
J.R. Gum, J.W. Hicks, N.W. Toribara, E.M. Rothe, R.E. Lagace, Y.S. Kim, The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. Journal of Biological Chemistry. ,vol. 267, pp. 21375- 21383 ,(1992) , 10.1016/S0021-9258(19)36620-7
Kermit L. Carraway, Kai Wu, Nevis Fregien, Molecular cloning and sequencing of the mucin subunit of a heterodimeric, bifunctional cell surface glycoprotein complex of ascites rat mammary adenocarcinoma cells. Journal of Biological Chemistry. ,vol. 269, pp. 11950- 11955 ,(1994) , 10.1016/S0021-9258(17)32665-0
Z Sheng, K Wu, K.L. Carraway, N Fregien, Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily. Journal of Biological Chemistry. ,vol. 267, pp. 16341- 16346 ,(1992) , 10.1016/S0021-9258(18)42007-8
Ismat A Khatri, Gordon G Forstner, Janet F Forstner, The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs Biochimica et Biophysica Acta. ,vol. 1326, pp. 7- 11 ,(1997) , 10.1016/S0005-2736(97)00063-1
P.M. Wassarman, Profile of a mammalian sperm receptor Development. ,vol. 108, pp. 1- 17 ,(1990) , 10.1242/DEV.108.1.1
S R Hull, Z Sheng, O Vanderpuye, C David, K L Carraway, Isolation and partial characterization of ascites sialoglycoprotein-2 of the cell surface sialomucin complex of 13762 rat mammary adenocarcinoma cells. Biochemical Journal. ,vol. 265, pp. 121- 129 ,(1990) , 10.1042/BJ2650121
Claudia Q. Lin, Mina J. Bissell, Multi-faceted regulation of cell differentiation by extracellular matrix. The FASEB Journal. ,vol. 7, pp. 737- 743 ,(1993) , 10.1096/FASEBJ.7.9.8330681
Kermit L. Carraway, Steven R. Hull, Cell surface mucin-type glycoproteins and mucin-like domains Glycobiology. ,vol. 1, pp. 131- 138 ,(1991) , 10.1093/GLYCOB/1.2.131
Yoji Shimizu, Stephen Shaw, Mucins in the mainstream Nature. ,vol. 366, pp. 630- 631 ,(1993) , 10.1038/366630A0
Kermit L. Carraway, Lewis C. Cantley, A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling Cell. ,vol. 78, pp. 5- 8 ,(1994) , 10.1016/0092-8674(94)90564-9