Short-term energy restriction reduces resting energy expenditure in patients with HIV lipodystrophy and hypermetabolism.

摘要: We have previously shown that resting energy expenditure (REE) is increased in patients with HIV lipodystrophy. This hypermetabolism could be the result of an inadequate storage capacity for lipid fuel secondary to atrophy subcutaneous adipose tissue depot. Therefore, restriction may able alleviate this hypermetabolism. To test hypothesis, we measured REE HIV-infected lipodystrophy and healthy controls. Measurements were taken during overnight fasted state after 3 days on a eu-energetic diet again similar composition but reduced by 50%. After feeding, was significantly higher compared controls (139.5 ± 1.3 vs 117.2 kJ/kg lean body mass, P < .001) tended subjects without 13 127.3 1.4 = .06). Furthermore, caused significant decline (P .001). dietary manipulation did not lead reduction either or suggests intake uniquely coupled as means dissipate cannot stored normal manner. A better understanding coupling would important implications weight regulation general.