Antiarrhythmic Effect of Reverse Ventricular Remodeling Induced by Cardiac Resynchronization Therapy

摘要: Objectives We investigated whether the reverse remodeling after cardiac resynchronization therapy (CRT) might reduce occurrence of ventricular arrhythmias (VAs). Background It is currently debated CRT has an effect on burden VAs. Methods The study included 398 patients treated with a defibrillator and follow-up at least 12 months. Spontaneous VAs detected by device were reviewed validated. Results A significant reduction in VA episodes shock therapies was evident during greater decrease 1 month. After 6 months CRT, 227 (57%) showed end-systolic volume ≥10% defined as “responders.” baseline characteristics similar between responders nonresponders. Nonetheless, proportion recurrence month significantly lower (32% vs. 43%, p = 0.024). Among variables no parameters emerged predictors tachyarrhythmia recurrence. However, receiver-operating curve analysis recognized left 13% best cutoff to identify (with sensitivity 58% specificity 54%). Conclusions In defibrillators, arrhythmic events occurs initial implant correlated degree induced therapy. Patients demonstrating midterm show soon implant, pronounced improvements long-term, better survival.