First stereoselective total synthesis of cryptomoscatone E1 and synthesis of (+)-goniothalamin via an asymmetric acetate aldol reaction
作者： Jhillu Singh Yadav , Dinesh Chandra Bhunia , Bogonda Ganganna , Vinay Kumar Singh
DOI: 10.1039/C3RA23167D
关键词: Intramolecular force 、 Organic chemistry 、 Aldol reaction 、 Chemistry 、 Stereochemistry 、 Stereoselectivity 、 Acetal 、 Total synthesis 、 Metathesis
摘要: A stereoselective total synthesis of (+)-goniothalamin and cryptomoscatone E1 have been described. The synthetic strategy involves an asymmetric acetate aldol reaction, Evans acetal intramolecular oxa-Michael ring-closing metathesis, Horner–Wadsworth–Emmons reaction lactonization as the key steps.
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