Noradrenergic and peptidergic innervation of lymphoid organs.

摘要: It now is evident that extensive neural-immune anatomical connections exist between the nervous and immune systems, with close contacts of nerves lymphocytes macrophages. The presence receptors for catecholamines neuropeptides on these cells, coupled functional evidence neural signals can modulate responses, brings putative neurotransmitters to forefront as a class immunomodulatory molecules be investigated possible benefit disorders resulting from enhanced or suppressed activity specific aspects function. Furthermore, feedback system (cytokines) act locally lymphoid organ innervation transmitter release, central via vagus nerve alter pathways relevant system. certainly very clear bidirectional interactions occur one cannot considered functionally without taking into account state other