Semaglutide contained oral prolonged-release preparation and preparation method thereof

摘要: The invention relates to a semaglutide contained oral prolonged-release preparation and method thereof. is characterized in that drug active component as GLP-1 analogue also prepared from sulfonylurea, biguanide or thiazolidinedione blood sugar lowering which has the synergistic effect withthe semaglutide; wrapped with sustained release carrier prepare microsphere, then microsphere mixed pressed witha pharmaceutically acceptable auxiliary material form tablet certain shape for orally use, so long-term exerted. By adopting preparation, conventional administration way of polypeptide changed, action time prolonged, medication compliance patient diabetesmellitus obviously improved, therapeutic improved.