How mammalian transcriptional repressors work
作者： Gerald Thiel , Michael Lietz , Mathias Hohl
DOI: 10.1111/J.1432-1033.2004.04174.X
关键词: YY1 、 Regulation of gene expression 、 Biology 、 Heterochromatin protein 1 、 Genetics 、 Gene silencing 、 Transcription (biology) 、 Repressor 、 GATAD2B 、 MECP2
摘要: Research on the regulation of transcription in mammals initially focused mechanism transcriptional activation and 'positive control' gene regulation. In contrast, repression 'negative was viewed rather as part 'prokaryotic book biology'. However, results obtained recent years have shown convincingly that mediated by repressor proteins is a common regulatory may play key role many biological processes. particular, fact human diseases, such Rett ICF syndromes well some forms cancer, are connected with activities indicates silencing essential for maintenance cellular integrity multicellular organism. The wide range diseases caused aberration sheds light importance understanding how mammalian work.
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