Chapter 2 Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation

摘要: Publisher Summary Neural stem cells (NSCs) are able to self renew for long periods, while retaining the capacity generate progenitor capable of producing neurons, astrocytes, and oligodendrocytes. Based on cell biology in other systems, NSCs their progeny should also be replacing lost or damaged brain tissue following injury disease. These two features have led many studies over past decade aimed at characterizing, isolating, expanding, transplanting these cells. One essential question before can used transplantation programs is related what actually happening when neural precursors expanded culture. All humans begin as a single fertilised zygote. This divides steady pace form blastocyst. From certain strain mice, inner mass from such blastocysts isolated maintained culture specialized feeder layers presence leukaemia inhibitor factor (LIF). embryonic (ES) qualify pluripotent cells, tissues all lineages.