Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases

摘要: Associations of cytochrome P450 (CYP) polymorphisms with risk disease development have been reported widely. For lung cancer, a large number studies on CYP1A1, CYP2D6, and CYP2A6 performed. However, recent studies, including meta-analyses genome-wide association suggest that only the association, where genotypes associated low activity decrease susceptibility possibly due to slower nicotine metabolism, appears significant. cancer also for CYP1A2, CYP1B1, CYP2E1 but these, though biologically plausible, not well replicated. cancers exposure xenobiotics other than tobacco smoke affects risk, CYP may be relevant. Examples include CYP3A hepatocellular carcinoma aflatoxin exposure, CYP1A2 colon heterocyclic arylamine nitrosamine-related nasopharyngeal cancer. diseases, well-established example relates CYP1B1 homozygosity rare mutations occurs in primary congenital glaucoma. Rare contribute more common forms CYP2C isoforms CYP2J2 extrahepatic metabolism arachidonic acid epoxyeicosanoic acids which effects cardiovascular system. Genotype these relevant evidence is still lacking. CYP2C19 poor metabolizers at increased endometriosis, genotype modulate alcoholic liver disease. In conclusion, are some diseases this overstated earlier studies.