Association between VHL single nucleotide polymorphism (rs779805) and the susceptibility to prostate cancer in Chinese.
作者： Jiawei Chen , Yilong Wu , Pengfei Shao , Qiang Cao , Chao Qin
关键词: Prostate-specific antigen 、 Oncology 、 Genotype 、 Case-control study 、 Internal medicine 、 Prostate cancer 、 Odds ratio 、 Biology 、 Bioinformatics 、 Single-nucleotide polymorphism 、 Carcinogenesis 、 Family history
摘要: The Von Hippel-Lindau (VHL) tumor suppressor gene is a crucial regulator of the hypoxia response pathway and plays an important role in tumorigenesis, particularly growth vascularization. We hypothesize that polymorphisms functional region VHL may influence susceptibility to prostate cancer (PCa). genotyped potentially polymorphism (rs779805) 5' UTR case-control study 665 PCa patients 715 cancer-free controls Chinese population using Taqman assay. genetic associations between incidence progression were assessed by logistic regression. observed rs779805 A>G was significantly associated with risk for PCa. Compared AA genotype, AG AG/GG genotypes decreased (adjusted odds ratio [OR]=0.79, 95% confidence interval [CI]=0.62-0.99, adjusted OR=0.76, CI=0.61-0.95, respectively). Further, this more pronounced subgroups nonsmokers (OR=0.73, CI=0.54-0.98), nondrinkers (OR=0.70, CI=0.54-0.91) without family history (OR=0.72, CI=0.57-0.92). In addition, variant (AG/GG) among specific antigen (PSA)>20 ng/mL subgroup (OR=0.68, CI=0.49-0.95). Our findings suggest confer population.
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