Activation Delay After Premature Stimulation in Chronically Diseased Human Myocardium Relates to the Architecture of Interstitial Fibrosis
作者： Tokuhiro Kawara , Richard Derksen , Joris R. de Groot , Ruben Coronel , Sara Tasseron
关键词: Heart failure 、 Sudden cardiac death 、 Ventricular fibrillation 、 Coronary artery disease 、 Cardiology 、 Internal medicine 、 Heart disease 、 Medicine 、 Heart transplantation 、 Dilated cardiomyopathy 、 Hypertrophic cardiomyopathy
摘要: Background— Progressive activation delay starting at long coupling intervals of premature stimuli has been shown to correlate with sudden cardiac death in patients hypertrophic cardiomyopathy. The purpose this study was elucidate the mechanism increased chronically diseased myocardium. Methods and Results— High-resolution unipolar mapping (105, 208, or 247 recording sites interelectrode distances 0.8, 0.5, 0.3 mm, respectively) epicardial electrical activity carried out during stimulation 11 explanted human hearts. hearts came from who underwent heart transplantation were end stage failure (coronary artery disease, 4; cardiomyopathy, 1; dilated 6). Eight Langendorff-perfused. Epicardial sheets taken remaining studied a tissue bath. Activation maps conduction curves constructed correlated histology. Conduction rev...
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