Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
作者： Antonios O Aliprantis , Ruey-Bing Yang , Melanie R Mark , Shelly Suggett , Brigitte Devaux
DOI: 10.1126/SCIENCE.285.5428.736
关键词: Respiratory burst 、 Inflammation 、 Toll-like receptor 、 Cell biology 、 Innate immune system 、 Programmed cell death 、 Monocyte 、 Cell activation 、 Biology 、 Immunology 、 Apoptosis
摘要: Apoptosis is implicated in the generation and resolution of inflammation response to bacterial pathogens. All pathogens produce lipoproteins (BLPs), which trigger innate immune response. BLPs were found induce apoptosis THP-1 monocytic cells through human Toll-like receptor–2 (hTLR2). also initiated an epithelial cell line transfected with hTLR2. In addition, stimulated nuclear factor–κB, a transcriptional activator multiple host defense genes, activated respiratory burst Thus, hTLR2 molecular link between microbial products, apoptosis, mechanisms.
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