Brain Metastases: The HER2 Paradigm

摘要: Between 100,000 and 170,000 patients with cancer develop central nervous system (CNS) metastases each year in the U.S., of which ∼20% carry a primary diagnosis breast cancer. As consequence improvements systemic therapy, have allowed to live longer advanced cancer, CNS are emerging as an important sanctuary site, incidence may be increasing particular tumor subtypes. Unless there treatment disease, growing proportion at risk experiencing both morbidity mortality result uncontrolled progression, often time when their extra-CNS disease is apparently under control. This article reviews changes epidemiology natural history women brain from HER2-positive over last decade presents therapeutic challenges opportunities that arisen this setting. First, apparent increase among relative historical controls, discussed, followed by consideration potential causes observation. Next, implications terms prognosis development preventive strategies considered. Finally, new developments approaches including cytotoxic chemotherapy targeted explored.