Viruses as Probes for Development and Differentiation

作者: Warren Maltzman , Arnold J. Levine

DOI: 10.1016/S0065-3527(08)60421-2

关键词: BiologyViral replicationDNAGene expressionGeneticsGeneRNARegulation of gene expressionMolecular virologyCellular differentiation

摘要: Publisher Summary This chapter presents study of viruses that has contributed in two important ways to a better understanding gene regulation and developmental biology. First, an analysis the processes viral replication itself provided new principles organization, DNA, RNA, protein synthesis, modification, processing. Second, use their expression probe biochemical genetic alterations developmentally interesting host cell begun provide useful insights into differentiated cells. Information from both these approaches come together more complete picture processes. A good example this can be illustrated with recent studies RNA The capping 5´ ends eukaryotic RNAs its utility synthesis observed reoviruse. Viruses have also been defining recognizing cellular genes even products. Just as identifying products, essential identification genes, phenotypes.

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