Adjuvant Radiation Therapy Treatment Time Impacts Overall Survival in Gastric Cancer

摘要: Purpose Prolonged radiation therapy treatment time (RTT) is associated with worse survival in several tumor types. This study investigated whether delays during adjuvant impact overall (OS) gastric cancer. Methods and Materials The National Cancer Data Base was queried for patients resected cancer who received Comprehensive Network–recommended doses (45 or 50.4 Gy) between 1998 2006. RTT classified as standard (45 Gy: 33-36 days, 50.4 Gy: 38-41 days) prolonged >36 days, >41 days). Cox proportional hazards models evaluated the association following factors OS: RTT, interval from surgery to initiation, completion, dose, demographic/pathologic operative factors, other elements of multimodality therapy. Results Of 1591 patients, delayed 732 (46%). Factors were non-private health insurance (OR 1.3, P =.005) at non-academic facilities 1.2, =.045). Median OS 5-year actuarial significantly compared (36 vs 51 months, =.001; 39 47%, =.005); worsened each cumulative week delay ( =.002); intervals initiation completion not. particularly detrimental node positivity, inadequate nodal staging Conclusions Delays appear negatively Efforts minimize interruptions