3-benzylidene-1-carbamoyl-2-pyrrolidone compounds useful as antiinflammatory agents
作者： Nobuhiro Haga , Susumu Kamata , Takeshi Shiota , Saichi Matsumoto , Toshihiko Okada
DOI:
关键词: Nitrogen atom 、 Stereochemistry 、 Aryl 、 Alkoxy group 、 Alkyl 、 Methylene 、 Hydrogen 、 2-Pyrrolidone 、 Halogen 、 Chemistry
摘要: The present invention relates to novel 3-benzylidene-1-carbamoyl-2-pyrroridone analogues having advantage anti-inflammatory activities, which is represented by the formula: ##STR1## wherein R1 and R2 each independently hydrogen, alkyl, alkoxy, or halogen; R3 hydrogen acyl; R4 hydroxy, cyano, R5 R6 aryl, aralkyl, heterocyclic group, substituted unsubstituted amino, OR7 R7 acyl, taken together with adjacent nitrogen atom may form group contain N, O, and/or S, X Y imino, methylene. In more detail, provides an agent useful for treatment of chronic inflammation has little side effect, e.g., stomach disease.
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