Variolins and related alkaloids

作者: Scott R. Walker , Erin J. Carter , Belinda C. Huff , Jonathan C. Morris

DOI: 10.1021/CR900032S

关键词: Human genomeChemistryCyclin-dependent kinaseBiochemistrySerineThreonineKinasePhosphorylationMetabolismTyrosine

摘要: The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518 protein kinases encoded in the human genome constitutes one of the major mechanisms used by …

参考文章(66)
Nigel B. Perry, Laurent Ettouati, Marc Litaudon, John W. Blunt, Murray H.G. Munro, Sean Parkin, Hakon Hope, Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Tetrahedron. ,vol. 50, pp. 3987- 3992 ,(1994) , 10.1016/S0040-4020(01)89673-3
Paul Schimmel, Jianshi Tao, Jason Hill, Aminoacyl tRNA synthetases as targets for new anti-infectives The FASEB Journal. ,vol. 12, pp. 1599- 1609 ,(1998) , 10.1096/FASEBJ.12.15.1599
A. M. Seldes, M. F. Rodriguez Brasco, L. Hernandez Franco, J. A. Palermo, Identification of two meridianins from the crude extract of the tunicate Aplidium meridianum by tandem mass spectrometry Natural Product Research. ,vol. 21, pp. 555- 563 ,(2007) , 10.1080/14786410601133517
Elke Bergmann-Leitner, Editorial [Hot Topic: Anti-Cancer Drugs Executive Editor: Elke Bergmann-Leitner] Current Pharmaceutical Design. ,vol. 15, pp. 730- 731 ,(2005) , 10.2174/138161208784246207
Pilar M Fresneda, Pedro Molina, Santiago Delgado, Juan A Bleda, Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin Tetrahedron Letters. ,vol. 41, pp. 4777- 4780 ,(2000) , 10.1016/S0040-4039(00)00728-0
Ángeles Mosquera, Ricardo Riveiros, José Pérez Sestelo, Luis A. Sarandeses, Cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines: synthesis of hyrtinadine A. Organic Letters. ,vol. 10, pp. 3745- 3748 ,(2008) , 10.1021/OL801393N
Laura Hernández Franco, Elisa Bal de Kier Joffé, Lydia Puricelli, Marcos Tatian, Alicia M. Seldes, Jorge A. Palermo, Indole alkaloids from the tunicate Aplidium meridianum Journal of Natural Products. ,vol. 61, pp. 1130- 1132 ,(1998) , 10.1021/NP970493U
Geoffrey I. Shapiro, Cyclin-dependent kinase pathways as targets for cancer treatment. Journal of Clinical Oncology. ,vol. 24, pp. 1770- 1783 ,(2006) , 10.1200/JCO.2005.03.7689
Pedro Molina, Pilar M. Fresneda, Santiago Delgado, Juan Antonio Bleda, Synthesis of the potent antitumoral marine alkaloid variolin B Tetrahedron Letters. ,vol. 43, pp. 1005- 1007 ,(2002) , 10.1016/S0040-4039(01)02321-8