Heterocyclic inhibitors of necroptosis
作者： Gregory D. Cuny , John A. Jr. Porco , Junying Yuan , Alexei Degterev , Xin Teng
DOI:
关键词: Necroptosis 、 Heterocyclic derivatives 、 Biochemistry 、 Chemistry 、 Tumor necrosis factor alpha 、 Jurkat cells
摘要: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. compounds the are described by Formulas (I) and (Ia)-(Ie) shown to TNF-α necroptosis in FADD-deficient variant human Jurkat T cells. further pharmaceutical compositions featuring invention. may also be used treat disorders where is likely play substantial role.
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lens.org参考文章(58)
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