The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells.

摘要: Eukaryotic cells can direct secretion to defined regions of their plasma membrane. These are distinguished by an elaborate architecture proteins and lipids that specialized capture fuse post-Golgi vesicles. Here, we show the Boi1p Boi2p important elements this area active exocytosis at tip growing yeast cells. Cells lacking accumulate secretory vesicles in buds. The essential PH domains interact with Sec1p, a protein required for SNARE complex formation vesicle fusion. Sec1p loses its localization depleted but overexpression partially compensate loss. capacity simultaneously bind phospholipids, multiple subunits exocyst, Cdc42p module generating identify as mediators between polar growth.