Characterization of Metabolomic Profile Associated with Metabolic Improvement after Bariatric Surgery in Subjects with Morbid Obesity.

摘要: The exact impact of bariatric surgery in metabolically “healthy” (MH) or “unhealthy” (MU) phenotypes for the study metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, 6 months after surgery. Multiple factor analysis, along correlation enrichment analyses, was carried out to distinguish those metabolites associated improvement. Hydroxypropionic acids, medium-/long-chain hydroxy fatty bile acid glucuronides were most discriminative biomarkers response between MH MU phenotypes. (hydroxyphenyllactic-related) amino glycerolipids significant clusters altered (p < 0.001). After surgery, changed toward a common state 3 observed negative changes waist circumf...