Genetic variation in microRNA genes and prostate cancer risk in North Indian population

作者: Ginu P. George , Ruchika Gangwar , Raju K. Mandal , Satya N. Sankhwar , Rama D. Mittal

DOI: 10.1007/S11033-010-0270-4

关键词: PopulationBone metastasisCarcinogenesisSingle-nucleotide polymorphismGenetic variationBioinformaticsOncologyInternal medicineGenotypeProstate cancerBiologymicroRNA

摘要: Recent evidence indicates the involvement of microRNAs (miRNAs), in cell growth control, differentiation, and apoptosis, thus playing a role tumorigenesis. Single-nucleotide polymorphisms (SNPs) located at miRNA-binding sites (miRNA-binding SNPs) are likely to affect expression miRNA target may contribute susceptibility humans common diseases. We genotyped SNPs hsa-mir196a2 (rs11614913), hsa-mir146a (rs2910164), hsa-mir499 (rs3746444) case–control study including 159 prostate cancer patients 230 matched controls. Patients with heterozygous genotype hsa-mir499, showed significant risk for developing (P = 0.01; OR 1.70 P ≤ 0.001; 2.27, respectively). Similarly, variant allele carrier was also associated cancer, 1.66 1.97, respectively) whereas, revealed no association cancer. None were Gleason grade bone metastasis. This is first on Indian population substantially presenting that individual as well combined genotypes miRNA-related variants be used predict useful identifying high risk.

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